Cagrilintide/semaglutide, marketed as CagriSema, is a combination of cagrilintide, a dual amylin and calcitonin receptor agonist, and semaglutide, a GLP-1 agonist. It is injected once weekly and is being tested in type 2 diabetes and obesity .

In a phase 2 trial of obese subjects, cagrilintide used in different subcutaneous doses once weekly was associated with a mean weight loss of 6-10.8% after 26 weeks, compared with 9.0% with the glucagon-like 1 receptor (GLP-1R) liraglutide (3 mg/d) and 3% with placebo at 26 weeks.

Aug 26, 2023 · Adults with type 2 diabetes and a BMI of 27 kg/m 2 or higher on metformin with or without an SGLT2 inhibitor were randomly assigned (1:1:1) to once-weekly subcutaneous CagriSema, semaglutide, or cagrilintide (all escalated to 2·4 mg).

Cagrilintide 2.4 mg demonstrates similar efficacy to semaglutide 2.4 mg and liraglutide 3 mg, with a reduced incidence of vomiting. Cagrilintide-based therapies offer the advantage of substantial weight loss with fewer gastrointestinal side effects, likely a major factor in determining long-term compliance and sustained weight loss.

Aug 26, 2023 · We found that treatment with co-administered semaglutide 2·4 mg and cagrilintide 2·4 mg (CagriSema) resulted in clinically relevant improvements in glycaemic control, including continuous glucose monitoring parameters, as well as significantly greater weight loss than either semaglutide or cagrilintide alone.

cagrilintide and semaglutide may exert a synergistic effect on weight loss but less than additive effect of HbA1c levels. This combination was associated with higher rates of GI adverse effects and mild hypoglycemia.

Dec 11, 2021 · Our study provides evidence that cagrilintide led to clinically significant, dose-dependent weight loss that was greater with cagrilintide at all doses versus placebo and greater with cagrilintide 4·5 mg versus liraglutide 3·0 mg.

May 8, 2021 · Safety, tolerability, pharmacokinetics, and pharmacodynamics of concomitant administration of multiple doses of cagrilintide with semaglutide 2·4 mg for weight management: a randomised, controlled, phase 1b trial

Jun 24, 2023 · SAN DIEGO — Coadministration of the long-acting amylin analog cagrilintide plus the glucagon-like peptide-1 (GLP-1) agonist semaglutide, dubbed CagriSema, resulted in significantly greater...

May 8, 2021 · Interpretation: Concomitant treatment with cagrilintide and semaglutide 2·4 mg was well tolerated with an acceptable safety profile. Future larger and longer trials are needed to fully assess the efficacy and safety of this treatment combination.