Sarcomas are generally classified into soft tissue sarcomas, such as fibrosarcoma, and bone sarcomas such as chondrosarcoma, which are rare cancers in adults accounting for about 1% of all cancer ...

In SMA, mitochondria in the skeletal muscles involved in voluntary movements don’t work properly, possibly contributing to ...

Processes such as mitochondrial fission, fusion, mitophagy, changes in membrane potential, reactive oxygen species (ROS) accumulation, and oxidative phosphorylation (OXPHOS) are all linked to drug ...

Here we report that TFE3 fusions transcriptionally rewire tRCCs toward oxidative phosphorylation (OXPHOS), contrasting with the highly glycolytic nature of most other renal cancers. Reliance on this ...

Reliance on mitochondrial metabolism in tumors cells presents a potential vulnerability that could be targeted via oxphos inhibitors to eliminate the residual surviving cells. Below, we first review ...