A new study led by scientists from BGI Genomics' Institute of Intelligent Medical Research (IIMR) has identified early ...

Huntington's disease has long defied attempts to rescue suffering neurons. A new study in Cell Reports shows that transplanting healthy human glial progenitor cells into the brains of adult animal ...

Our findings indicate that liver-specific SMN depletion does not induce motor neuron death, neuromuscular pathology or muscle atrophy, characteristics typically observed in the Smn2B/- mouse at P19.

Author response: The following is the authors’ response to the original reviews. Public Reviews: Reviewer #1 (Public review): Summary: This manuscript presents a comprehensive exploration of the role ...

A reassessment of spinal cord pathology in severe infantile spinal muscular atrophy: reassessment of spinal cord pathology. Neuropathol Appl Neurobiol. 2024;50 (5):e13013. doi:10.1111/nan.13013 ...

A study of cells from 84 cadaver brains suggests that Alzheimer's has two distinct phases, and that one type of neuron is especially vulnerable. "There's an early phase where there's a very slow ...

December 6, 2023 A neuromuscular junction (motor end plate), an axon of a motor neuron, and a striated skeletal muscle fiber (cell). [Ed Reschke / Getty Images / Stone] ...

Researchers who previously developed the first 3D human cell culture models of Alzheimer’s disease (AD) that displays two major hallmarks of the condition—the generation of amyloid beta deposits ...

When this electrical impulse reaches the end of an axon, the neuron releases chemicals called neurotransmitters into the synapse. The chemicals wander across the gap and stick to specific ...

Indeed, AD synapses had 3.3 times more T22-reactive tau than p-tau231, an early marker of tau pathology. With or Without Tangles.In areas with both few (top) and many (bottom) neurofibrillary tangles ...

Cajal continued to write and to encourage his students, even on his deathbed in 1934. His final paper, written that year, was a detailed recapitulation of the neuron doctrine.