New research reveals that Alzheimer's disease may impair nerve function not by reducing myelin, but by altering the proteins ...

Scientists isolate and identify these proteins by tandem mass spectrometry (Bar et al., 2018). Cai focused on the paranode, where the ends of myelin sheaths bracket a node of Ranvier. An antibody ...

"It seems that the total amount of the myelin in the myelin sheaths is relatively preserved," says Grutzendler. Nerves are coated in myelin, but have tiny gaps called "nodes of Ranvier" where the ...

Nerves are coated in myelin, but have tiny gaps called “nodes of Ranvier” where the nerve is exposed to boost signals. Right next to these gaps are “paranodes,” where the myelin sticks tightly to the ...

The axo-myelin unit is a sophisticated structure that includes the myelin sheath, the axon beneath, and the nodes of Ranvier. The nodal-paranodal axon cytoskeleton, anchorage molecules, and even the ...

These problems—less energy, loss of myelin, and damaged neurons—start early, but the actual death of the brain cells tends to happen later, as the disease becomes more severe.

The Innovation Center of NanoMedicine has summarized the results of its collaborative research with Professor Kanjiro ...

Panelists discuss how chronic neuroinflammation involves distinct mechanisms from acute relapses—including microglial ...

Myelin – produced by Schwann cells in the periphery and oligodendrocytes in the CNS – is defective in diseases such as multiple sclerosis, and many myelin repair strategies aim to mitigate ...