Iran and Israel exchanged more deadly missile strikes overnight Friday after Israel mainly attacked Iranian nuclear and military targets one day earlier.

In sweeping attacks that started early Friday, Israel has struck at the regime in Tehran, targeting Iranian nuclear and military assets. The Israeli strikes have killed more than 70 people, including four top security chiefs, and damaged Iran’s main nuclear site at Natanz.

Follow live updates as Iran retaliates after Israel strikes nuclear facilities. Stay informed with real-time news and developments.

Iran's top diplomat Abbas Araghchi said Saturday that Israel's strikes on his country were undermining nuclear talks with the United States. Araghchi, in a call with Russia's Foreign Minister Sergei Lavrov,

Fox News’ Alex Hogan and Mark Meredith report on the strikes between Israel and Iran, and reaction from the United States. Heritage Foundation senior fellow Brent Sadler joins ‘Fox News Live’ to analyze the future of Iran’s nuclear program.

The United States is the main international backer of Israel, Iran's biggest regional foe. It is also a close ally of Sunni Gulf monarchies which for years pursued their own rivalry with the Islamic Republic, seeing it as their main regional threat.

Tehran said American bases in the Middle East could face reprisals if the U.S. helped repel Iranian attacks on Israel.

The United States has pulled some diplomatic staff and military families out of the Middle East, citing unspecified regional security risks.

Israel’s leader and President Trump appeared to bet they can persevere, but other world leaders warned of unintended outcomes in a volatile region.