Iran and Israel exchanged more deadly missile strikes overnight Friday after Israel mainly attacked Iranian nuclear and military targets one day earlier.

The Iron Dome is designed to protect Israeli citizens by launching guided missiles to intercept incoming rockets and other short-range threats in mid-air.

DUBAI, United Arab Emirates (AP) — Israel’s defense minister warned Saturday that “Tehran will burn” if Iran continues firing missiles, as the two countries traded blows a day after Israel launched a blistering surprise attack on Iranian nuclear and military sites, killing several top generals.

Israel's initial assault used warplanes and drones to hit key facilities and kill top generals and scientists.

Iranian officials on Saturday signaled they could walk back their decision to not attend upcoming nuclear talks with the U.S., but said further negotiations were likely “meaningless” as the nation exchanges fire with Israel.

Israel struck at the heart of the Iran's nuclear program, killing several nuclear scientists as well as high-ranking military leaders, according to Israeli officials. The U.S. did not provide any military assistance or have any involvement in the Israeli strike, a U.S. official told ABC News.

Iranian state media report more explosions, with blasts heard in Tehran, as Israel says its air force is hitting military targets.

DUBAI, United Arab Emirates — Israel’s defense minister warned Saturday that “Tehran will burn” if Iran continues firing missiles on Israel after at least three people died and dozens were wounded Saturday morning, following a series of blistering Israeli attacks on the heart of Iran’s nuclear program and its armed forces.

DUBAI, United Arab Emirates (AP) — Israel’s defense minister warned Iran on Saturday that “Tehran will burn” if it continues firing missiles. Speaking after an assessment meeting with the army’s chief of staff, Defense Minister Israel Katz said that Iran will pay a heavy price for harming Israeli citizens.

Israel said its overnight attack targeted the "heart" of Iran's nuclear programme. Those strikes killed Hossein Salami, the chief of Iran's powerful Islamic Revolutionary Guards military branch, plus several senior military figures and nuclear scientists. Civilians, including children, were among those killed, Iran said.

Defense Sec. Hegseth confirmed that President Trump is "dialed in" to the Israel-Iran conflict on "Fox & Friends" Friday and assured that this is not an "autopen moment" for the president.