Between two adjacent myelin segments, there are approximately 1-μm-long gaps called nodes of Ranvier (Figure 1A and E). At the nodes, the axon is exposed to the extracellular space. Axonal ...

3D reconstruction of electron microscopy images showing a perinodal astrocyte (blue), node of Ranvier (gray), compact myelin (purple), and layers of myelin detaching from the axon (tan).

Myelin insulates the axon by assembling specialized structures at the nodes of Ranvier. This myelination of nerves greatly increases the speed that signals (referred to as action potentials) are ...

image: Using newly developed markers, the scientists were able to visualize axons, myelin, and nodes of Ranvier in vivo. A version of this image is used in the current article in Current Biology ...

Cai focused on the paranode, where the ends of myelin sheaths bracket a node of Ranvier. An antibody against contactin-associated protein 1 (CASPR), an adhesion protein that anchors these ends, fished ...

Nerve fibers are surrounded by a myelin sheath. Scientists at the Technical University of Munich (TUM) have now made the first-ever "live" observations of how this protective layer is formed.

Discovered by French scientist Louis-Antoine Ranvier in 1878, these tiny nodes have been known since 1939 to act like relay stations placed about 1 millimeter apart along the myelinated nerve to ...

The transmission speed of neurons fluctuates in the brain to achieve an optimal flow of information required for day-to-day activities, suggests a new study. The results, appearing in PNAS, suggest ...

Patients lacking laminins have abnormally thick and instable myelin, short internodes and immature nodes of Ranvier. We first determined that laminin 211, dystroglycan and certain integrins are ...

Myelin surrounds and insulates the axon and builds specialized molecular structures at small, uncovered gaps in the sheath, which are referred to as the nodes of Ranvier.