Real Madrid has confirmed a second injury to a first team star which will likewise severely affect planning for a Champions League showdown with Manchester City.

Real Madrid central defender Antonio Rüdiger has been diagnosed with a leg muscle injury sustained in a Spanish league game on Saturday.

Elsewhere among the eight ties, Celtic meet Bayern Munich and there is an all-French contest between minnows Brest and serial domestic champions Paris Saint-Germain. The first legs of the play-off matches will take place on February 11 and 12, with the returns a week later.

Manchester City secured their place in the UEFA Champions League knockout round play-off with their 3-1 win over Club Brugge. Following that win Pep Guardiola’s side could have been drawn against

Real Madrid vs. Manchester City is now a familiar sight in the Champions League. European soccer’s most engrossing rivalry in recent years will resume in a two-legged playoff next month to reach the round of 16.

Real Madrid take on Manchester City in the Champions League as two of the biggest clubs in Europe fight for a spot in the round of 16. Real Madrid should be favored to go through given the team's recent form.

Real Madrid confirmed a huge injury blow which will severly affect head coach Carlo Ancelotti’s plans for this month’s Champions League clash with Manchester City.

Real Madrid will play Manchester City in the Champions League knockout playoffs round in a standout clash of the past two title winners after the draw was made Friday.