The San Francisco Giants, as expected, officially placed Landen Roupp on the 15-day injured list with left knee inflammation on Friday although there remained no word as to how much time the right-handed starting pitcher might be forced to miss.

But his addition to the roster to start Friday against the Milwaukee Brewers was necessitated by another injury to Landen Roupp. Earlier in the summer, the productive right-hander was dealing with inflammation in his right elbow.

The SF Giants have called up left-handed pitcher Carson Whisenhunt who will get the ball on Friday night against the Milwaukee Brewers. He has a chance to redeem himself after his struggles when he was first called up.

The Padres tied a game they shouldn’t have trailed in the fourth inning, scored six runs in the fifth inning with help from a two-error play and survived a burst of a comeback powered by back-to-back homers off Dylan Cease at the start of the sixth.

Pregame analysis and predictions of the Los Angeles Dodgers vs. San Diego Padres MLB game to be played on August 22, 2025 on ESPN.

San Francisco Giants (61-66, fourth in the NL West) vs. San Diego Padres (71-56, second in the NL West)

BOTTOM LINE: The San Diego Padres face the San Francisco Giants on Wednesday. San Diego has a 70-56 record overall and a 39-21 record at home. Padres hitters are batting a collective .251, which ranks fourth in the NL.

The San Francisco Giants (61-67) visit the Milwaukee Brewers (80-48) for the opener of a 3-game series Friday. First pitch from American Family Field is set for 8:10 p.m. ET. Let's analyze BetMGM Sportsbook's MLB odds around the Giants vs. Brewers odds and make our expert MLB picks and predictions for the best bets.